3-Chloro-4-Fluoroaniline CAS 367-21-5 Gefitinib Intermediate Purity >99.5% (HPLC)

Short Description:

Chemical Name: 3-Chloro-4-Fluoroaniline

CAS: 367-21-5

Purity: >99.5% (HPLC)

Appearance: White to Off-White Crystals

Intermediate of Gefitinib (CAS: 184475-35-2)

Contact: Dr. Alvin Huang

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Product Detail

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367-21-5 - Description:

Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of 3-Chloro-4-Fluoroaniline (CAS: 367-21-5) with high quality. Ruifu Chemical can provide worldwide delivery, competitive price, excellent service, small and bulk quantities available. Purchase 3-Chloro-4-Fluoroaniline, Please contact: alvin@ruifuchem.com

Gefitinib Intermediates:

Gefitinib	CAS 184475-35-2
3-Chloro-4-Fluoroaniline	CAS 367-21-5
4-(3-Chloropropyl)morpholine	CAS 7357-67-7
4-(3-Chloro-4-Fluorophenylamino)-7-Methoxyquinazolin-6-ol	CAS 184475-71-6
7-Methoxy-6-(3-Morpholin-4-ylpropoxy)quinazolin-4(3H)-One	CAS 199327-61-2
6-Methoxy-7-Hydroxyquinazolin-4-One	CAS 162012-72-8

367-21-5 - Chemical Properties:

Chemical Name	3-Chloro-4-Fluoroaniline
Synonyms	4-Fluoro-3-Chloroaniline; 3-Chloro-4-Fluorobenzenamine; m-Chloro-p-Fluoroaniline
Stock Status	In Stock, Commercial Production
CAS Number	367-21-5
Molecular Formula	C6H5ClFN
Molecular Weight	145.56 g/mol
Melting Point	42.0~47.0℃(lit.)
Boiling Point	227.0~230.0℃(lit.)
Flash Point	110℃
Density	1.226 g/cm3
Stability	Stable. Incompatible with strong oxidizing agents, acids, acid chlorides, acid anhydrides, chloroformates. May be air-sensitive.
COA & MSDS	Available
Sample	Available
Origin	Shanghai, China
Brand	Ruifu Chemical

367-21-5 - Specifications:

Items	Inspection Standards	Results
Appearance	White to Off-White Crystals	Off-White Crystals
Water by Karl Fischer	<0.50%	0.19%
Residue on Ignition	<0.10%	<0.10%
Single Impurity	<0.50%	0.09%
Total impurities	<0.50%	0.30%
Purity / Analysis Method	>99.5% (HPLC)	99.7%
1H NMR Spectrum	Consistent with Structure	Complies
Conclusion	The product has been tested and complies with the given specifications

367-21-5 - Package/Storage/Shipping:

Package: Fluorinated Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.
Storage Condition: Keep the container tightly closed and store in a cool, dry and well-ventilated warehouse away from incompatible substances. Protect from light and moisture.
Shipping: Deliver to worldwide by air, by FedEx / DHL Express. Provide fast and reliable delivery.

Advantages:

Sufficient Capacity: Sufficient facilities and technicians

Professional Service: One stop purchasing service

OEM Package: Custom package and label available

Fast Delivery: If within stock, three days delivery guaranteed

Stable Supply: Maintain reasonable stock

Technical Support: Technology solution available

Custom Synthesis Service: Ranged from grams to kilos

High Quality: Established a complete quality assurance system

367-21-5 - FAQ:

How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.
Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.
Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.
Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers.
Factory Audit? Factory audit welcome. Please make an appointment in advance.
MOQ? No MOQ. Small order is acceptable.
Delivery Time? If within stock, three days delivery guaranteed.
Transportation? By Express (FedEx, DHL), by Air, by Sea.
Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.
Custom Synthesis? Can provide custom synthesis services to best fit your research needs.
Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.

367-21-5 - Safety Information:

Risk Codes R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed.
R33 - Danger of cumulative effects
R36/37/38 - Irritating to eyes, respiratory system and skin.
R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed.
Safety Description S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
UN IDs UN 2811 6.1/PG 2
WGK Germany 2
FLUKA BRAND F CODES 9-23
TSCA T
HS Code 29214200.90
Hazard Note Irritant/Toxic
Hazard Class 6.1
Packing Group III
Toxicity LD50 orally in Rabbit: 506 mg/kg

367-21-5 - Application:

3-Chloro-4-Fluoroaniline (CAS: 367-21-5) is used as an organic synthesis intermediate, pharmaceutical intermediate, or chemical reagent.

3-Chloro-4-Fluoroaniline is an important starting material of Gefitinib (CAS: 184475-35-2). Gefitinib is an antineoplastic target therapy drug with relatively high specificity that was developed by the British pharmaceutical company AstraZeneca; it is the first molecular targeted drug to be used in non-small cell lung cancer treatment.